The resulting overall calcium response in the cell, deduced from the combination of the nuclear and the cytosolic calcium response might contribute to the specificity of the final response to a specific stimulus.
Based on the results above, we hypothesized that additional sequence-specific transcription factors may contribute to the specificity of the fasting response at a subset of CREB sites.
Additionally, the Ar/R (an aromatic amino acid and Arginine) selectivity filter also contributes to the specificity of the channel by providing a size barrier and effectuating proton exclusion (reviewed in refs. 3,8,17,18,19).
All residues examined were found to contribute to the specificity for phosphate (Arg135, Leu343, Tyr344), fructose (Tyr132, Asp342) or both (Pro134, Tyr196, His234, Gln345).
The retained ligands have significant influence on protein‐binding properties, with the complex shape and coordination preferences of the metal ion (donor type and geometry) both contributing to the specificity and strength of the binding interactions.
Here, we discuss the biophysical (ligand receptor geometry and affinity) and cellular (receptor trafficking and intracellular abundance of signaling molecules) parameters that contribute to the specificity of cytokine bioactivities.
The design of vaccines that induce robust and long-lasting protective CD8 T-cell responses however imposes new challenges, as many factors such as kinetics and efficiency of antigen-processing and presentation by antigen presenting cells, T-cell repertoire and cytokine environment during T cell priming contribute to the specificity and functionality of CD8 T-cell responses.
