Similar to the effects of compromising mutations in the SLIDE domain of ISW2 on repositioning efficiency and directionality of nucleosome translocation, the ATP binding and hydrolysis cycle of ISWI may contribute to the random walk behavior that we observe.
Each of the subsequences was then examined to determine whether CAP binding to the primer rather than the sequence from the random library contributed to the extraction of the sequence.
Binary trees were built by recursively partitioning explanatory variables into high and low categories that significantly contributed to the prediction of outbreak versus random locations [42].
This relatively small number of random trials contributed to the non-smoothness in the data, but this sufficiently illustrates the trend of relationship between the parameters.
Another possible explanation would be that even if the ancestral sequences were not beneficial to the species, random sampling contributed to the elimination of other alleles and the fixation of these sequences in the downsized population, creating a new lineage, due to natural catastrophe or population migration, referred to as a "genetic drift" or "population bottleneck" [ 27].
If invited subjects who did not want to participate comprised more tobacco smokers than those who actually participated, such non-random self-selection might have contributed to the observed positive dose-response association with tobacco consumption.
However, numerous other factors also contribute to the non-random distribution of malaria infections, such as human demography and behaviour, immune history and current health status, and access to adequate health services.
Any or all of these factors could contribute to the non-random deposition of plaques in the vicinity of a pre-existing plaque.
High host specificity and phylogenetic conservatism in host use was observed (Additional file 1: Figure S2; Figure 4), the latter likely contributing to the non-random pattern of associations among hosts and myzostomids.
Thus, haplo-insufficiency of multiple genes, each with a small effect, could contribute to the non-random pattern of LOH observed in ovarian cancer, especially for chromosomal regions that are weighted towards CNL-LOH such as 8p and X, rather than CNN-LOH, such as 17.
