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C-G collected the P. americana seeds and contributed to the preparing the CHCl3 and EtOH extracts.
All authors contributed to the preparing of the manuscript and also read and approved the final manuscript.
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XL prepared extant and fossil material, contributed to the preparation of figures, and drafted the manuscript.
MU contributed to the data analyses, prepared and edited the manuscript.
CT also contributed to the study design, prepared the zebrafish embryos, helped performed the experiments and co-wrote the manuscript.
NR contributed to the study design by preparing the final report and drafting the manuscript.
All authors contributed to the data analysis and prepared Additional files 1, 2, 3, 4, 5, 6 and 7. DW drafted the manuscript and CS provided critical revisions.
KMEA contributed to the modelling analyses and prepared the manuscript.
AM critically evaluated the manuscript and contributed to the writing process and prepared the final draft.
NP designed, conducted and analysed the ecological research, contributed to the phylogenetic analysis, and prepared the manuscript.
HG conceived the concept of the index 'Treatment Duration Control' and the related RCT procedure, contributed to the data analysis and prepared the manuscript.
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