Sentence examples for contributed to the activation from inspiring English sources

To determine if c-Src activity contributed to the activation of Ras by hypoxia, we pretreated Caco2 cells with PP2, a potent and selective Src tyrosine kinase inhibitor.

It is therefore possible that the effects of exogenous Akt2 expression on invasion of these cells were enhanced by the contribution of HER-2/ neu or that HER-2/ neu overexpression contributed to the activation of the other Akt isoforms that led to the increased invasion by Akt2 overexpression [ 1].

Thus failure to produce sufficient mir-21 may well have contributed to the activation of these pathways.

Failure to process mir-21 may have contributed to the activation of these signalling pathways, while such impairment hints at a wider problem with miRNA formation and hence control of tissue phenotype.

As predicted by the correlation analysis, we found that while only the go trials contributed to the activation of right IPL and right SMA, go trials and no-go trials contributed equally to the activations in left LO and left pIPS.

To validate this in silico analysis, functional experiments in thyroid cancer cell lines demonstrated the presence of a functional TGFA/EGFR autocrine signaling loop, which sustained the proliferation of PTC cells and contributed to the activation of the PI3K/AKT pathway independent of MEK/ERK pathway.

We thus propose that the elevated c-Src activity contributes to the activation of Stat-3 and Fak in ILC cells.

Collectively, our results point to CDK9 Ser175 as novel PP1-regulatory site which dephosphorylation upregulates CDK9 activity and contribute to the activation of HIV-1 transcription.

Ras activates Raf-1 and contributes to the activation of PI3K (with FAK).

(4) We propose that the activity of single, or multiple, NLMS neurons contributes to the activation of small populations of premotor tectal neurons (assemblies).

Depression and anxiety are also associated with increased activity in the amygdala which may contribute to the activation of pain-facilitating pathways [35].