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The RAD52Y104pCMF displayed diminished dsDNA-binding capacity that contributed to targeting of RAD52Y104pCMF specifically to ssDNA and facilitated annealing of ssDNA and ssDNA RPA complexes.
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Our findings suggest that the participation of community groups can contribute to targeting these transport-related social issues, especially with respect to accessibility to opportunities.
This suggests that as yet unidentified structures or mechanisms could contribute to targeting of the basal body at the far posterior end.
Drosophila Polycomb (Pc or M33 in mouse), a core subunit of PRC1, selectively binds to histone H3 tail peptide trimethylated at K27, suggesting that H3K27me3 may contribute to targeting of PRC1 to HOX genes [28], [29].
By analogy, it could be that a virally encoded product contributes to targeting KAP1 to the HCMV genome.
Variations exist, and amino acids upstream of the terminal tripeptide also contribute to targeting (Brocard and Hartig, 2006).
However, they might still contribute to targeting to various tissues or proteins as they are fully exposed on the surface of these enzymes.
Given an association between long 3'UTR and NMD, it is possible that both long 3'UTRs and an exon junction complex downstream of a PTC contribute to targeting.
Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy resistance, including in the highly lethal brain cancer glioblastoma (GBM).
Thus, we are very optimistic that our effort will contribute to targeted drug discovery.
Our results suggest that PEI-GO is a potentially efficient nonviral transfection reagent that may contribute to targeted cancer therapy.
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