Sentence examples for contributed to target from inspiring English sources

Genetically modified mice provide models for Alport syndrome evolving to renal failure that have resulted in clinical recommendations, polycystic kidney disease models that have provided clues for the development of tolvaptan, that was recently approved for the human disease in Japan; and animal models also contributed to target C5 with eculizumab in hemolytic uremic syndrome.

The magnitude of translational repression due to miRNA-mediated deadenylation may depend on the extent to which the poly(A) tail contributed to target mRNA translation before removal; this will vary between mRNAs and with the functional state of the cellular translational machinery.

The RAD52Y104pCMF displayed diminished dsDNA-binding capacity that contributed to targeting of RAD52Y104pCMF specifically to ssDNA and facilitated annealing of ssDNA and ssDNA RPA complexes.

5' end sequences are critical for miRNA function [2], [41], [71] [73] and the seed region is thought to contribute to target recognition by perfect (or near perfect) complementary binding to the mRNA target site.

Base-pairing elsewhere in the miRNA, including at a so-called T1A site extending the seed region [3] and in the 3' region [3], [4], has also been variously proposed to contribute to target binding.

Together, these observations suggest that cytokines, particularly IFN-alpha, may contribute to target organ damage.

Furthermore, beyond seed site pairing, the centre and the 3′end of the miRNA sequence can contribute to target recognition.

Thus, our data do not support the notion of TiA contributing to target cell resistance in the murine system.

The project aims to contribute to target 17 of the Millennium Development Goals: 'in cooperation with pharmaceutical companies, [to] provide access to affordable, essential drugs in developing countries'.

It is believed that the amphipathic nature of LfcinB allows interaction with the abundant negative charges present in cancer cells, thus contributing to target selectivity [ 34, 44].

This would in turn suggest that they contribute to target specificity, as their sequences are different from the canonical miRNAs from the same pre-miRNAs.