Sentence examples for contributed to sensitizing from inspiring English sources

We demonstrated for the first time that the knockdown of endogenous BMI-1 expression contributed to sensitizing osteosarcoma cells to the anticancer drug cisplatin by increasing apoptosis.

In this study, we demonstrated for the first time that the knockdown of miR-21 expression by a miR-21 inhibitor contributed to sensitizing human glioma cells to the anticancer drug taxol.

The above results argue in favor of a local release of CGRP in the meninges, where this neuropeptide may contribute to sensitizing local sensory neurons.

Avicin D-induced dephosphorylation of Stat3 and the subsequent inhibition of its transcriptional activity, contributes to sensitizing the cells to apoptosis.

This review summarises some of the current knowledge concerning the role of NFAT signaling in the innate immune response and the recent advances on NFAT-dependent inhibition of NOD1-mediated innate immune response caused by CsA, which may contribute to sensitizing transplant recipients to bacterial infection.

This potent neuromodulator is stored in the terminal branches of Aδ and C fibers where it's release into the joint lowers the activation threshold of nociceptive nerve endings, which is likely to contribute to chronic, sensitized pain responses [ 52].

In total, our findings support the general notion that polyglutamine aggregate-formation contributes to neurodegeneration by sensitizing cells to physiologic or environmental stress.

However, to our knowledge, no study has examined whether changes in muscle transcripts contribute to the insulin sensitizing effect of TZDs in PCOS patients.

Additionally, loss of miR-326 in MCF-7/VP multidrug-resistant cell lines contributed to the overexpression of MRP1, whereas enforced levels of this miRNA sensitized MCF-7/VP to VP-16 and doxorubicin (Liang et al. 2010).

This drift of thought sensitized Pico to the fulminations of Girolamo Savonarola, the "mad monk," and it may have contributed to his death.

All these biochemical mediators can sensitize muscle nociceptors and thus indirectly contribute to central sensitization and chronic pain.