Indomethacin pretreatment may reduce sensitivity to NGF through several mechanisms, including anti-inflammatory effects in the joint, reduced afferent barrage to the spinal cord, and direct effects on glial cells that contribute to sensitisation in rat OA models.
The subsequent enhancement of glutamatergic signalling would either stimulate NTS output neuron activity, thus contributing to sensitisation-induced airway hyperresponsiveness.
20 In this study, sensitisation to storage mites was independently associated with allergic rhinitis.
Chronic preoperative pain may contribute to central sensitisation from longstanding exposure to nociceptive input (Wilder-Smith et al, 2002).
The next experiments investigated whether TRPV1 contributes to the sensitisation of knee joint afferents in the MIA model of OA pain.
To investigate whether modulation of intracellular polyamine levels could be contributing to the sensitisation of the SW480 cells to I3C by putrescine, intracellular putrescine, spermidine and spermine levels were measured after treatment with I3C in the presence or absence of putrescine.
There are other mechanisms, however, that may also modulate TRPV1 function Sugiura et al 41 reported data from a mouse model suggesting that 5-hydroxytryptamine (5-HT, serotonin) receptor activation may enhance the responsiveness of the TRPV1 receptor to acid and temperature, and thereby contribute to peripheral sensitisation.
The same PDC structure has contributed to establishing an effective role for parish level actors in problem analysis, planning, resource management and advocacy/sensitisation in the community.
Inhibition of MEK/ERK1/2 and PKC by STP or UCN-01 can both contribute to their VA sensitisation effect in thoracic cancer cells, yet the relative contribution of each to this effect is not clear at present.
