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These findings echo recent studies which showed how variations in sample characteristics and analysis methods contributed to large differences in minimally important change values [ 30].
The teams made small and gradual changes in the methodology, which may have contributed to large differences in the assessments over time.
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Overall the measured differences between siblings are a small fraction of that determined among the accessions; over repeated generations, however, drift in the copy number of these elements could contribute to large differences.
However, small, gradual methodological changes together with continuingly developed expertise and adaption to looking at harm from a patient's perspective may contribute to large differences in assessment over time.
However, the significant differences between groups shown in this study cannot be contributed to large samples, which is a strength of our findings.
These nucleotide analogs have a biotin moiety attached to the 5 position of the pyrimidines (C and U) or the 7 position of the purines (A and G) via a chemically cleavable azido-based linker, with different length linker arms serving as mass tags that contribute to large mass differences among the nucleotides.
These varied experiences contribute to large economic differences across groups.
The limited vernalization the plants received in the growth chamber may have contributed to the large differences between populations in bolting time, but photoperiod requirements were probably a larger factor.
This pooled analysis was planned from the inception of both studies, which contributed to avoid large differences between studies, with regard to data collection and analysis [14].
This evolutionary process has also contributed to the large difference in the number of MHC genes between species within a given mammalian order [8].
Low prevalence of trauma-related disability also contributed to the large difference between the negative and positive predictive values.
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