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These anti-inflammatory effects of sulforaphane may also contribute to its role in migraine treatment.
There are several circuits within the hypothalamus that contribute to its role in integrating appetite, the melanocortin pathway being the most well understood.
Although C. difficile is an obligate anaerobe when in its vegetative state, its spores have been estimated to persist on dry, inanimate surfaces for months [3], contributing to its role as a major nosocomial pathogen.
Palladin contains two different conserved domains that contribute to its role as an actin-binding scaffolding molecule: proline-rich domains that are hot-spots for protein-protein interaction, and Ig domains that mediate F-actin crosslinking [15].
The impaired healing associated with diabetes may contribute to its role as a significant risk factor for leak (34).
These unique properties of APOE ε2 may contribute to its role in the etiology of lipid associated diseases including psoriasis.
Similar to IRS-1, IRS-2 has also been implicated in promoting tumor cell survival, which is likely to contribute to its role in tumor progression.
We propose that the ability of p16INK4a to inhibit the cyclin D-dependent kinases and DNA replication, functions not shared by p21Waf1, contribute to its role in senescence.
RGC32, SESN1 and BAX (all up-regulated) are all targets of p53 contributing to its role in cell cycle regulation, metabolism and apoptosis [ 56- 58].
47, 48 Thus, the hypoxic regulation of ECM dynamics may contribute to its role in metastatic dissemination and ECM-modifying enzymes could potentially be targeted by anticancer agents.
Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com