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The prognostic value of cyclin A overexpression may well be contributed to its interaction with large sized, undifferentiated, OR-negative breast tumours with an increased proliferative capacity (Table 4).
Experiments with a truncated UvrD1 derivative that lacked the 90aa C-terminal extension (a construct equivalent to residues 1 650 of E. coli UvrD) showed that the C-terminus of the protein contributed to its interaction with Ku, but was not essential for Ku-UvrD1 interactions as the truncated protein was still stimulated by Ku in helicase assays [35].
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We investigated the structural basis for chemokine binding to GAGs by using in vitro mutagenesis to identify amino acids of chemokine macrophage-inflammatory protein-1 beta (MIP-1 beta) that contribute to its interaction with the model GAG heparin.
The 'flexibility' of the NES region in Rio2 contributes to its interaction with Crm1 in the presence of RanGTP.
Harrison et al. (2007) previously showed, by point mutagenesis and crystallography approaches, that three surface-exposed basic patches in the LG4 5 domains of laminin-111 contribute to its interaction with α-dystroglycan.
Similarly, multiple PDGF-binding sites on perlecan (also known as HSPG-2) contribute to its interactions with this protein (Göhring et al., 1998; Goretzki et al., 1999).
The adsorption mechanism was explored and discussed based on π π affinity, hydrophobic effect, hydrogen bonding and electron donor acceptor (EDA) interaction, which contributed to its strong recognition affinity to target compounds.
The stacking interactions with Phe226 also contributed to its tight binding to 1A2.
Previous research has shown that Hcp2 of E. coli RS218 contributes to its interaction with HBMECs [ 70].
Dimerization of Nup53 contributes to its membrane interaction and is crucial for its function in NPC assembly.
A high surface energy and wettability of the Ta surface were observed to contribute to its significantly better cell material interactions.
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