Genes contributing to enrichment scores of the most enriched processes per quadrant at 72.3 hr of aging (sterol biosynthesis from Q1, translation regulation from Q2, cortical actin cytoskeleton from Q3, and endoplasmic reticulum from Q4) are shown highlighted for each time point to illustrate their changes.
Since we use the Fisher's exact test based enrichment method for pathway-level consistency analysis, the outliers could work together with other relevant genes of high and/or low end expressers to contribute to enrichment scores, which otherwise would be reduced to less significant levels.
From this analysis, we concluded that the slight age difference between the samples did not contribute to enrichment of CpG sites that show a strong correlation with age.
Significantly enriched terms were selected based in part on the number of genes contributing to enrichment, and in part on the annotations.
To assess underlying biology in the COO-classified and COO-unclassified meta-profiles we developed an approach for integrated analysis of GO and gene signature enrichment (Additional file 2) which applies hierarchical clustering to reciprocally assess the relationships of enriched ontology and signature terms and associated genes contributing to enrichments (Additional file 6).
> -wrap-foot> identifierier, PW pathway, NES normalized enrichment score aThe number of genes that were mapped to a pathway and contributed to the enrichment score calculation The normalized enrichment score, p, q, and gene count for the 17 top ranking pathways (FDR < 0.2) are listed in Table 1.
While carrier-specific probes contributed to the enrichment of the biological process inflammatory response (4 probes, p < 0.05), no GO enrichment was identified among survivor-specific probes.
Yet by that logic, the opium trade and slavery should also be reintroduced, since they also contributed to the enrichment of many countries.
Shortly after the American Film Institute was founded, they created an award to honor someone whose career has "greatly contributed to the enrichment of American culture".
