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VP contributed to elaboration of the manuscript.
RG contributed to elaboration of data.
GW contributed to elaboration of data.
AL contributed to elaboration of the clostridial database Anaeroscope.
RE conceived the mathematical formulae and contributed to elaboration of the manuscript.
RNPB and DSL participated in the design of the study and contributed to elaboration of this manuscript.
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Finally, our findings lead us to hypothesise that the evolution of many of these CNEs contributed to the elaboration of the vertebrate hindbrain and the branchial region of the head.
CGJ contributed to the elaboration of the protocol of study, and helped in the interpretation of data.
AC performed the US study, contributed to the elaboration of the protocol of study, and helped in the interpretation of data.
The characterization of activating mutations has contributed to the elaboration of a model involving the extracellular domain of the receptor as an inverse tethered agonist which, upon binding of the ligand, relieves the transmembrane domain from an inhibiting interaction and activates it.
All the authors contributed to the elaboration of the protocol, its feasibility and the preparation of the manuscript.
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