It was demonstrated that besides necrosis and apoptosis, autophagy was apparently associated with PEI-induced cytotoxicity and contributed to aggravated cell damage.
Besides, although IL-17A production by Th17 cells was limited in the current study, this does not preclude the possibility that IL-27 may also contribute to aggravating the pathogenesis of postinfluenza pneumococcal pneumonia by inhibiting Th17 development at later time-points.
Systemic insults, such as prolonged inflammation, severe hypoxemia, and persistent hyperglycemia also may contribute to aggravate sepsis-induced brain dysfunction or injury.
In addition to these factors, others contribute to aggravate these problems, such as: the application of unpredicted loads, due to different uses and architectural modifications of the structure; foundation settlement; wrong structural conception; natural deterioration of the materials and components; and, impacts, collisions or explosions.
These observations suggest that increased BMI contributes to aggravated arterial alteration, independently of age.
The pathophysiology of acute brain injury is complex and can involve several secondary pathological cascades that contribute to aggravate neuronal injury.
Our findings that sequential pro-inflammatory insults result in decreased expression of IL-1ra and IL-10, cytokines that can modulate the effect of inflammatory mediators in the hypothalamus, may further contribute to aggravate the alterations referred to.
On the other hand, the air mass approach may characterize situations more relevant to meteorological conditions (for example, heat waves) that contribute to aggravated health outcomes and not necessarily due only to, or associated with, elevated pollution levels.
Additionally, our studies demonstrated that short-term exposure to PM2.5 contributed to aggravate cardiac function in myocardial infarction rats.
Diagnosing brain dysfunction in a patient with sepsis implies a systematic diagnostic approach of all potential factors, in addition to sepsis, that can contribute to aggravate or prolong brain dysfunction.
