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P63 deficiency was found to induce cellular senescence and to cause an accelerated ageing phenotype in adult mice showing the conditional expression or depletion in stratified epithelia contributed to ageing [ 29, 30].
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Highly reactive particles called free radicals are made naturally in the body and cause damage to cells, while smoking, ultraviolet light and other environmental factors contribute to ageing.
In addition, cells which have entered senescence persist in tissue, and take on an altered, deleterious phenotype which is thought to contribute to ageing.
[ 54] Similarly, excess redox stress is felt to contribute to ageing.
Mitochondrial dysfunction often leads to increased oxidative stress and contributes to ageing.
Similarly, in yeast, mitochondria contribute to ageing through their propensity to generate reactive oxygen species [ 40, 41].
On the other hand, limiting cell division prevents tissue renewal and repair and thus contributes to ageing.
For example, we saw that DNA damage is highly dependent on age, which is in agreement with our hypothesis (and that of many other scientists) that DNA damage may contribute to aging and aging-related diseases," he adds.
Multiple biological consequences of oxidative stress are known to contribute to aging and aging-related pathologies.
Studies during the past several years have demonstrated that the mTORC1 signaling pathway contributes to aging and metabolism.
Oxidative stress contributes to aging and may cause alterations in pain and analgesia.
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