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It contributed to a significant extent to the increased sensitivity that investors now have regarding the ability of sovereign countries to pay back their debts, especially in Europe.
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This, together with the observed higher exposure to the metabolite compared with the parent compound after single-dose administration indicates that the metabolite will contribute to a significant extent to the pharmacological activity of macitentan.
In an ideal case, the liquefying component(s) potentially already present in the pre-hydrolysis mixture would contribute to a significant extent to the efficient saccharification of the substrate, and thus reduce the overall enzyme requirement.
If rare functional SNPs in and around LPL are contributing to a significant extent to the association of the gene with TG levels, then rare haplotypes sharing the same lineage might prove informative, as outlined recently in a modelling paper (16).
This contributed to a significant drop in overall prices for electricity bought wholesale by large consumers.
Rust: They definitely contribute to a significant amount of greenhouse gas emissions.
Experimental uncertainties have also contributed to a certain extent.
Both authors contributed to a similar extent overall.
All authors contributed to a similar extent overall.
All the authors contributed to a similar extent overall.
Less problems of insomnia (p = .058) contributed to a lesser extent to a higher alcohol consumption.
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