Elevated expression of these genes would work to drive down levels of cAMP, which could contribute to a breakdown of endothelial barrier properties, and modify responses to inflammatory mediators [82], [83].
The interpretation to have evidence of a similar volume effect between these two different classes of preparations under intensive care conditions [ 7] might be, on the one hand, quite justified, as critical illness might significantly contribute to a breakdown of the vascular barrier [ 29].
This distancing has contributed to a breakdown in feelings of solidarity in the face of vulnerability and has had troubling effects on relationships between social workers and families.
Release of autoantigens within P2X7-stimulated aponecrotic debris may also contribute to a breakdown in self-tolerance and initiation of autoimmunity.
A conservative theologian, Pope Benedict repeatedly warned that contraception was one of a host of trends contributing to a "breakdown in sexual morality".
Tony and Cherie Blair's former "lifestyle coach", Carole Caplin, has revealed that she regrets ever having worked for the former prime minister and his wife because of the resulting press coverage, which contributed to a "sort of breakdown" two years ago.
The resulting homogenization in turn fortifies uniformity, as the two distinct legal cultures are altered by their mutual encounters, adapting to the imperatives of coexistence and coalescence, and in turn reinforcing homogenization, as their acquired adaptive characteristics contribute to a further breakdown of distinctive legal attributes by processes of reciprocal influence and blending.
Music played an increasing part, with Carl Davis composing a fine score for a Pericles in 1973 that was largely set in the brothel at Mytilene, and Donald Fraser (with whom McCulloch started an affair that contributed to the breakdown of the marriage) scoring Christopher Logue's War Music in 1977.
