Mathematical models at varying levels of inhibition have and are expected to continue contributing in distinct ways to understanding the regulation of PCP signaling.
Alternatively, progerin may induce stochastic epigenetic alterations that affect distinct gene sets, each of which contributes in distinct ways to the onset of the progeroid phenotypes.
Specifically, it has been shown that the fission yeast chromodomain proteins Swi6, Chp1 and Chp2, although found at both centromeric and telomeric heterochromatin, contribute in distinct ways to heterochromatin assembly at these loci (Thon and Verhein-Hansen, 2000; Partridge et al, 2000, 2002).
However, MitoQ (which will not interact with the Golgi apparatus) did not rescue bar mutants, indicating that the two different subcellular pools of CoQ10 contribute in quite distinct ways to the phenotype.
Thus, the interaction between the PR70 holoenzyme and its substrates might be contributed in part by electrostatic potential highly distinct from that of the B′ holoenzymes.
Rational choice of an appropriate target however poses significant challenges as we move from linear models of cytokine effector function in chronic inflammation, to a 'network concept' of interacting activities contributing in synergy across distinct tissue events.
Differences in select gene and protein expressions within sedentary and active animals occurred with age and contributed to distinct health-related phenotypes in adulthood.
The degree to which different burst mechanisms and currents contribute to bursting in distinct subpopulations of dopamine neurons [59, 60] in vivo is an open question.
Growing evidence suggests that human immunodeficiency virus type one (HIV-1) infection of the central nervous system (CNS) may affect some of these functions and contribute to neuropathogenesis in distinct pathways (reviewed in [6] [8]).
Here we address the question whether RPL24B and eIF3h contribute to reinitiation in distinct ways or similar ways.
