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Hence, the "controls" were patients who did not receive alteplase in neuroprotection trials but received either placebo or a neuroprotective drug as per the randomisation protocol for each contributing trial.
This is not straightforward in practice: reviewers must decide how to handle missing outcome data in the contributing trials.
Values of EC50 and the Hill coefficient (see next section) are assumed identical in the contributing trials or between populations.
As the contributing trials spanned 30 years, the types of chemotherapy used varied considerably and consequently the pre-specified main analysis sub-divided trials into chemotherapy categories.
AF will contribute to trial design, methods and data management and be responsible for data quality, analysis and reporting.
R.B.J. contributed to trial design, and led trial conduct and manuscript preparation.
In this matching procedure trials were not used more than once, but the same participant could contribute different trials to both conditions.
The absence of clear communication between trial participants and trial investigators contributed to premature trial closures in at least two sites [ 1, 2].
MD contributed to trial design and protocol development, had overall responsibility for conduct of the trial, and contributed to recruiting patients, deciding the statistical analysis, interpreting the data and preparing the manuscript.
An article last Friday about the money contributed by trial lawyers to Republican races in Texas misstated Steve Mostyn's title at the Texas Trial Lawyers Association.
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