Consistent with these previous reports, the lower ROS levels resulted from MoSEC22 disruption may partly contribute to the defects of ΔMosec22 mutants.
Of these genes, 4 have been implicated previously in aspects of CNS development, raising the possibility that their increased transcription could contribute to the defects of neural development in Hdac1-deficient embryos.
Both altered β-cell function and decreased β-cell mass are likely to contribute to the defects in insulin release typical of diabetes.
First, we focus on the factors contributing to the defects in FSW of aluminium alloys.
Importantly, this suppression is also associated with an improvement in fitness in most disomic strains, particularly under proteotoxic stress conditions, suggesting that defects in redox homeostasis contribute to the proliferation defect of aneuploid strains.
Thus, loss of TEMRA might contribute to the functional defect of PD-1hiTIM-3+ T cells.
From the observed metabolic imbalance we inferred that accumulation of intermediates of the methionine pathway upstream of AecD or the lower pool size of the downstream intermediates could contribute to the growth defect of C. glutamicum cells at acidic pH.
show that the DC infiltration pattern is altered along the adenoma-carcinoma sequence and that the COX-2 increase might contribute to the functional defect of DCs in CRC.
It provides evidence that diabetes via AGEs may contribute to the functional defects of the endothelium in pathological situations by causing the dysfunction of EPCs.
Interestingly, the latter two are also targets of Csr1 in C. albicans (18), which might contribute to the filamentation defect in the absence of CSR1.
