Sentence examples for contribute to target from inspiring English sources

Identification of therapeutic targets, which are involved in the survival of CML LSCs such as bcl-2; the self-renewal such as sonic Hh, bmi-1, notch, and Wnt; and the block differentiation such as JAK2/STAT5 activation and HOX gene hypermethylation, will contribute to target LSCs effectively using combinations of small molecule inhibitors and demethylating agents.

5' end sequences are critical for miRNA function [2], [41], [71] [73] and the seed region is thought to contribute to target recognition by perfect (or near perfect) complementary binding to the mRNA target site.

Base-pairing elsewhere in the miRNA, including at a so-called T1A site extending the seed region [3] and in the 3' region [3], [4], has also been variously proposed to contribute to target binding.

Together, these observations suggest that cytokines, particularly IFN-alpha, may contribute to target organ damage.

Furthermore, beyond seed site pairing, the centre and the 3′end of the miRNA sequence can contribute to target recognition.

This would in turn suggest that they contribute to target specificity, as their sequences are different from the canonical miRNAs from the same pre-miRNAs.

Thus, we are very optimistic that our effort will contribute to targeted drug discovery.

Our results suggest that PEI-GO is a potentially efficient nonviral transfection reagent that may contribute to targeted cancer therapy.

Our findings suggest that the participation of community groups can contribute to targeting these transport-related social issues, especially with respect to accessibility to opportunities.

Our results suggest that PEI-GO is effective in the delivery of siRNA and may contribute to targeted gene therapy to suppress cancer metastasis.

Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy resistance, including in the highly lethal brain cancer glioblastoma (GBM).