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Together, the NMR data therefore would probably be most consistent with PK9119 binding outside of the hydrophobic pocket in a cleft on the other side of the hydrophobic pocket divider, although interpretations are difficult due to sidechain reorganisation and other conformational changes that can contribute to shift perturbation.
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However, they also reveal a reluctance of central government to contribute to shifting social norms.
Pharmacogenomic technologies can contribute to shifting the pharmaceutical industry from its traditional blockbuster model of drug development towards a more personalised and preventive approach.
Routinizing testing may thus contribute to shifting the decision from the moral realm testing because of reprehensible behavior to the health realm testing as a standard part of prenatal care and for the baby's health.
There seemed to be a long laundry list of why venture capital was undergoing this shift, but never any thread that could lay out all the factors and synthesize just how each factor contributed to shift, until now….
In addition, the positioning of the center of gravity of the first rotational transition is discussed, with several factors contributing to shift it from the 14.7 meV of the gas phase.
Rapid urbanization, change in dietary patterns, behavioural factors and major improvements in prevention of maternal and child health to raise life expectancy are all factors contributing to shift disease patterns in Nepal [ 14].
Some studies of drug use and gambling have also contributed to shifting the thinking about addiction.
Across Sub-Saharan Africa, the roll-out of antiretroviral treatment (ART) has contributed to shifting HIV care towards the management of a chronic health condition.
Defining how different environmental features contribute to shifts in β-diversity is especially important as these shifts reflect both spatio-temporal variations in species richness and the degree of ecological separation between local and regional species pools.
In addition, new techniques for estimating species richness that explicitly incorporate species turnover [11], [12] allow investigations of how different environmental features contribute to shifts in species richness across ecological landscapes [13].
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