Sentence examples for contribute to mutation from inspiring English sources

Since inserts may inactivate or activate genes, they are likely to contribute to mutation burden.

The reprogramming process itself can contribute to mutation rates: nuclear genomic mutations arise during reprogramming and are selected against during subsequent culture (Hussein et al., 2011).

Although there are limited data so far, there is an expectation that mobile element insertions will contribute to mutation of driver genes in cancers.

Previous analyses of the HPRT mutational spectrum [ 38– 45] had revealed structural features in DNA that probably contribute to mutation induction at the HPRT locus, for example, missense mutations due to single base substitutions leading to amino acid substitutions; nonsense point mutations leading to premature stop codons and truncated proteins; deletions leading to the loss of enzyme activity.

At the same time, our postulated saturation-induced mutator phenotype might contribute to mutations in genes encoding proteins that act in DNA repair, such as mutS, resulting in hypermutable P. aeruginosa strains.

Diesel exhaust and many individual substances contained in it (including arsenic, benzene, formaldehyde and nickel) have the potential to contribute to mutations in cells that can lead to cancer.

There are multiple factors that could contribute to mutations.

Finally, since error-prone repair or TLS of oxidized DNA lesions will contribute to mutations, we hypothesized that MutS and DinB play opposing roles in P. aeruginosa pathoadaptation.

Endogenous sources of mutagens may also contribute to mutations in cancer.

Oxidative stress can contribute to mutations in regulatory genes, including tumor suppressors such as p53 and PTEN (phosphatase tensin homolog) [ 31].

SMC contributed to mutation analysis using mass spectrometric genetic analysis ("Asan-Panel"), interpretation of the results and drafting of the manuscript.