It has been hypothesized that HERV-K expression contributes to evade immune-surveillance in immune-competent mice, thus promoting the growth of transformed cells and stimulating tumour progression [ 63, 77].
miR-195 contributes to evading apoptosis, sustained angiogenesis, cell growth, tissue invasion and metastasis.
A number of metabolic traits were identified in C. pecorum that may contribute to its ability to evade the host immune system and enable persistent infections to be established in the host.
While EMT has been widely studied for its role in early development and, more recently, cancer metastasis, it may also contribute to a cellular ability to evade the effects of platinum-based therapies.
Mechanisms that enable prostate cancer cells to evade apoptosis may contribute to therapeutic resistance.
In addition, reduced mitochondrial activity might contribute to the ability of cancer cells to evade apoptosis.
In many cancers, including myeloid malignancies, impaired immune function is thought to contribute to disease progression by allowing tumor cells to evade the immune system [ 49].
This hypothesis, if further supported by data, could contribute to our understanding of how HIV-1 evades immune responses and offer new concepts for design of effective vaccine immunogens.
Our data suggested that human stem cells may use similar mechanisms to evade the recognition by NK cells and contribute to the immune-privileged properties of these cells.
Collectively, our data suggest that reduced DDR activity may contribute to therapy resistance in NSCLC by allowing these cells to evade cell death in the face of extensive treatment-inflicted DNA damage.
