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Genomic approaches represent unbiased and powerful tools to uncover the molecular basis of these complex mechanisms and they may also contribute to discover new biomarkers for these diseases.
Overall, sno/scaRNAs deregulation in plasma cell dyscrasias adds a further level of complexity to the heterogeneity of these forms and may contribute to discover new biomarkers and altered molecular pathways associated with the disease.
These data extend the view of sno/scaRNAs deregulation in cancer and may contribute to discover novel biomarkers associated with the disease and potentially useful to predict the clinical outcome of early stage CLL patients.
This finding indicates that the meta-analysis of GWAS datasets including even more different populations would contribute to discover more loci with moderate effects that would probably remain undetected because of population heterogeneity due to the limited number of individuals in the current populations.
In conclusion, our data extend the current view of ncRNA deregulation in cancer pointing to the potential relevance of the sno/scaRNA family in the context of CLL which may contribute to discover novel putative molecular markers associated with the disease.
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This study aims to contribute to discovering how young children's social and emotional skills can be supported.
This phenomenon is likely to occur in other lichen-forming fungi, which would contribute to discovering the mechanism of the algal switch [ 93- 95] and could provide clues for the evolution of lichenization.
Scientifically, too, it paid off: In the 7 months Cruz stayed there, the new group contributed to discovering seven supernovae.
Gene expression data in two pairs of samples at disease/normal states contributes to discovering genes and metabolites that can be potential biomarkers.
Here, we discuss how this KIBRA-aPKC connection, a potential regulator of membrane trafficking and cell polarity, can contribute to the recently discovered functions of KIBRA.
Both drugs were originally developed as cytarabine analogues to be used at high doses as antimetabolites, until their ability to target epigenetic changes that contribute to leukemogenesis was discovered.
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