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The p53 inducible gene, CSPG2, performed best in separating OO kidneys from adults and OA samples in this analysis.The method described in this study using independent validation samples can be envisioned to test utility of the identified genes in assessing age-related changes that contribute to decline in renal function.
CONCLUSION Consistent with past studies, depressed elders exhibit greater cognitive decline than nondepressed subjects, particularly individuals with early depression onset, supporting the theory that repeated depressive episodes may contribute to decline.
The majority of interviewees in both study sites were of the opinion that transhumant practices contribute to decline in the availability of forage resources and annual production of vegetation.
These effects can in turn affect the PGE2 biosynthetic pathway and further contribute to decline local inflammation and clinical benefit.
This effect may contribute to decline in muscular force production and overall performance.
Thus, anti-cancer mechanisms may contribute to decline in stem cell function and may inadvertently promote affects that we know as ageing.
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Another serious dip in the stock market could contribute to declining spending on drilling in 1988.
Future studies should continue to explore factors that contribute to declining physical function after deployment.
Atherosclerosis in both large arteries and in the microvasculature appears to contribute to declining kidney function [ 8, 9].
We have previously shown that insulin resistance can contribute to declining β-cell function in Hispanic women (13, 15).
Chronic asymptomatic pyuria may increase the risk of developing overt UTI and may contribute to declining renal function in ADPKD.
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