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By enhancing the antioxidant ability of hepatocytes, through transgene vectors, one could counteract oxidative/nitrosative stress and, in this way, contribute to blocking the progression of liver disease.
Including this interaction data would significantly strengthen the authors' model that Irgb2-b1CIM binding to ROP5 may contribute to blocking Irga6 phosphorylation in CIM mice.
Ret inhibition also decreased Ret expression levels and lowered the activity of the Fak signalling pathway, all of which could contribute to blocking metastatic spread.
This reality forms the evolutionary backdrop to the environmental antibiotic resistome: the collection of all the genetic elements that contribute to blocking the action of molecules toxic to bacteria.
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Animal fats and vegetable oil, lard, grease, butter and margarine, food scraps and dairy products all contribute to blocked drains, "fatbergs" and sewer blockages.
Antibodies directed against specific antigens and conjugated to toxins may contribute to block tumour vascularisation.
Therefore, an additional increase in GSH by NAC may contribute to block ESA-mediated apoptosis.
However, and although GH is able to stimulate the IgfI mRNA transcription in progeroid cells, the increased levels of miR-1 may contribute to block IGF-1 protein synthesis.
Our finding that significant antineoplastic activity could be achieved with a single VDA treatment followed by repeated administrations of PTX indicates that one treatment is enough to compromise tumour growth, as long as chemotherapy or other forms of treatment contribute to block tumour progression.
This situation contributed to blocking the biofuel dossier at the level of the Ministry of Agriculture and explains in part the ministry's limited involvement in the building of the policy and regulatory framework for the sector.
Although thrombin cleavage of Dab2 might lead to the loss of Dab2 inhibitory activity in a platelet aggregation assay [9], we hypothesize that Dab2 binding to sulfatides at the platelet surface could protect the protein from thrombin cleavage (our results) while contributing to blocking sulfatides needed for pro-coagulant interactions [20].
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