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How does water contribute to binding?
Apart from the base-recognition residue, the other residues in a TALE repeat may also contribute to binding affinity.
In addition to these polar interactions observed in the structure, the N- and C-terminal extensions of ATRXDBM may also contribute to binding with DAXXDHB through electrostatic interactions.
SH3 domains have a conserved surface that recognises proline-rich peptides in ligand proteins, but additional contacts also contribute to binding.
Several distinct patches of hydrophobic residues at the ACE2 surface were noted at close proximity to the charged ridges that could contribute to binding.
Favorable intermolecular interactions are observed in the MD simulations for the residues that were previously shown to contribute to binding in an Ala scan of NT.
Similar(7)
Such "dissection" of binding into contributions from different groups suggested that the adenine moiety contributed to binding of nucleotide independently of Mg2+ ions.
This confirms that SF contributes to binding by increasing chloride ion adsorption on the additional C S H produced by the pozzolanic reaction (Luping and Nilsson 1993).
The structures reveal a shared binding element, Phe76, that contributes to binding as part of both PAM2-N and PAM-C.
The formamide NH⋅⋅⋅Cl− is longer than ideal, but presumably contributes to binding.
This site can therefore be considered as primarily important for signaling without contributing to binding.
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