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The findings suggest that this targeted modulation of matrix loss by hormones may contribute selectively to degeneration of specific synovial joints.
In the present study, we report that two other skin DC subtypes, pDCs and LCs, contribute selectively to distinct stages, initiation and propagation, of the inflammatory process in the skin according the model shown in Supplementary Fig S6. pDCs were shown previously to be abundantly present within both lesional and non-lesional skin of psoriatic patients (Nestle et al, 2005).
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Taken together, these results suggest that neurabin contributes selectively to LTP but not LTD in the hippocampal CA1 pyramidal neurons.
There is a component of motor learning in the VOR, which is highly sensitive to disruption of P/Q signaling, and which contributes selectively, although not exclusively, to changes in the temporal properties of the VOR.
Signaling through P/Q-type voltage-dependent calcium channels, which are highly expressed in the cerebellum, contributes selectively to the regulation of the temporal properties of movements, with a very limited role in the regulation of movement amplitude.
Boyden et al. 2006 provided evidence that one specific climbing fiber-triggered plasticity mechanism, long-term depression of the parallel fiber-to-Purkinje cell synapses, (pf-Pk LTD) contributes selectively to VOR-increase but not VOR-decrease learning.
Because the region including this loop is partially conserved in Twi1p (Fig. 2E), we hypothesized that this region could contribute to selectively load 5′ U scnRNAs to Twi1p.
The last section of the Discussion has been expanded to discuss how both the morphological changes and the intrinsic hyperexcitability might contribute to selectively protect S-type motoneurons in ALS.
More generally, our results demonstrate that P/Q signaling contributes selectively, but not exclusively, to learned changes in the temporal properties of the VOR.
Complex III and IV selectively contribute to the ∆MICOS phenotypes.
These findings imply that relaxin and β-estradiol selectively contribute to the degeneration of fibrocartilaginous tissue by differentially modulating MMP expression, matrix synthesis, and net matrix content.
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