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We have specifically noted where individually-randomised trials contribute outcome data.
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We originally estimated about 1000 patients would contribute outcomes to this study and made our power calculations assuming a 10∶5 ratio of intervention to control clusters with balanced numbers of participants in each cluster and no matching.
The TAU group will only contribute outcomes to the trial data set under the TAU condition.
Figure 2 shows that, of the 118 eligible children enrolled who provided baseline data, 107 (91%) contributed outcome data.
NEB had primary responsibility for protocol development and contributed outcome assessment, preliminary data analysis, and writing the manuscript.
Of 25 included studies, 18 were RCTs including 64,852 participants and seven were non-RCTs – five case control studies and two cohort studies including 62,294 participants; the non-RCTs contributing outcomes for culture-confirmed invasive pneumococcal disease (IPD) only.
Twenty-five studies contribute 1 outcome each to this sum, while nine studies contribute 2 outcomes each, seven studies contribute 3 outcomes each, and one study contributes 4 outcomes.
Anatomical reduction and rigid internal fixation are the two important surgeon controlled factors that may contribute to outcome.
Genetic factors might be postulated to contribute to outcome, and indeed to causation of MTLE + HS.
Additionally, host response during infection is likely to contribute to outcome.
The extent to which different types of music contribute to outcomes also remains open to question.
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