They fail to consider ways in which depleted capital accumulation, investment in human capital, and demographic change contribute to diminished economic growth.
The resulting recast layer from EDM often exhibits high levels of residual stress, unacceptable crack density and high surface roughness; all of which will contribute to diminished surface integrity and reduced fatigue life.
Therefore, the neurodegenerative phenotypes observed in XPA patients may be attributed to decreased cellular survival in both NSCs and neurons upon DNA damage, as accelerated apoptosis in either NSCs or neurons could contribute to diminished number or dysfunction of mature neuronal cells, leading to neurodegeneration.
Since TRPA1 is gated by, and is permeable to Ca2+ [19], it is possible that reduced expression of the channel might also contribute to diminished Ca2+ currents and enhanced excitability after injury.
To examine whether inactivating mutations might contribute to diminished HOXC9 expression in neuroblastoma, we sequenced the genomic HOXC9 locus of 46 primary tumors with low HOXC9 expression.
Further, the elevation of lecticans in AD and aging suggests this matrix has the potential to contribute to diminished synaptic plasticity [ 19, 20].
These include obesity, a component of the 'metabolic syndrome', 7 and reduced bone mineralisation that can result in frank osteoporosis 8; both disorders contribute to diminished physical activity and carrying the burden of morbidity and mortality.
However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain suggesting that besides a decrease on BDNF levels a reduction of TrkB expression could also contribute to diminished neurotrophic support in HD.
Insulin, which is also increased in our model, stimulates collagen synthesis in vascular smooth muscle cells (Ruiz Torres et al. 1998) and could contribute to diminished vasorelaxation in MS rats.
