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In addition to enzymatic barriers, physical barriers also contribute difficulty in bioavailability of orally administered protein drug (Goldberg and Gomez-Orellana 2003).
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Some of these factors seem likely to contribute to difficulty in quitting smoking, suggesting, perhaps, difficulty in accessing cessation support and advice.
Therefore, in so far as anatomic factors contribute to difficulty, it may be unsurprising that we did not find any change in difficulty between early and late reintubation.
Unfortunately, the nonspecific symptomology can contribute to difficulty making a diagnosis.
Cognitive, language and learning delays contribute to difficulty with literacy development, but environmental factors also play a role.
The nuclear background in which these mtDNA haplotypes are found is a factor that may contribute to difficulty in detecting and interpreting correlations between mitochondrial haplogroups and longevity.
Loss of physical strength may contribute to difficulty in actuating a pressurized MDI.
Unsuspected PE may also contribute to difficulty in weaning patients from mechanical ventilation [ 12].
These complicated conditions may contribute to difficulty in establishing clear exercise guidelines for CKD patients.
This can contribute to difficulty in completing education, social isolation, lack of family support, poorer employment opportunities and continuing poverty.
may also contribute to difficulty falling asleep and waking up.
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