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In rapidly ageing populations, particularly those in developing countries, mortality statistics tend to be inaccurate or incomplete, and do not reflect those conditions that do not cause death but contribute chiefly to morbidity and disability [ 10].
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These mineralogical memoirs, contributed chiefly to the Royal Academy of Sciences of Turin, were distinguished by a profound knowledge of crystallography.
Of the coeditors, Alexander Pfänder contributed chiefly to the development of phenomenological psychology and pure logic but developed also the outlines of a complete phenomenological philosophy.
Occurrence of sulphate in river water is mainly natural in nature contributed chiefly by mineral sources like gypsum, etc.
Inertinite, which ranges from 5.1%to9.9%9% (mean 7.9%) (3.6%–11.0%, mean 7.4% on mmf basis), is contributed chiefly by funginite, inertodetrinite and fusinite whereas other macerals of this group occur in very low concentration.
Electron microscopy of fractured surfaces reveals widespread fiber/matrix interface debonding and fiber pullout, which chiefly contribute to cyclic cracking resistance.
Sporinite, cutinite, resinite, and liptodetrinite chiefly contribute to liptinite group while fusinite, funginite, and inertodetrinite are the main inertinite macerals.
Taking VEGF signaling pathway as an example, we further extract a core set of gene pairs that chiefly contribute to the variation of p53 status.
In addition, our method is advantageous in that the use of the minimum p-value can reduce the irrelevant gene combinations and extract core sets of gene interactions that chiefly contribute to the statistical variation of a phenotype of interest.
Thus for each identified gene set with enriched gene interactions, we will extract a core set of gene pairs that chiefly contribute to the statistical variation of a phenotype of interest.
It has been proposed that apoptosis and senescence of cardiac progenitor cells chiefly contribute to the pathogenesis of anthracycline cardiomyopathy, as depletion of these cell population hinders the ability of the heart to regenerate in response to minor injuries which, thereby, accumulate and affect cardiac structure and function [ 35, 36].
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