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Surprisingly, contrary to previously suggested data [11], all S96 mutant proteins showed undisturbed microtubule-associated pattern.
The trend found in the overall signaling network is exemplified by analysis of the distribution of purifying selection along the mammalian Ras signaling pathway, showing that, contrary to previously suggested in Drosophila, upstream and downstream genes evolve at similar rates.
In any case, these results indicate that, contrary to previously suggested in Drosophila[ 37], genes acting at the upstream part of the mammalian Ras pathway are not subject to higher levels of selective constraint than those acting at the downstream part.
Contrary to previously suggested in Drosophila[ 37], genes acting at the upstream part of the mammalian Ras pathway (those encoding the Grb2, SOS1, SOS2, H-Ras, K-Ras, N-Ras, A-Raf, B-Raf, and C-Raf proteins) were not found to exhibit lower rates of evolution than those acting at the downstream part (the rest of genes listed in Additional file 1: Table S5).
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Numerical tests show convergence behavior superior to previously suggested algorithms.
This is contrary to previously published data suggesting that the NER is more efficient in ES cells compared to terminally differentiated cells and appears to be dependent on the cell cycle processes [ 44].
Moreover, contrary to previously published work [11], doxorubicin treatment of U2OS cells induces phosphorylation at the serine 536 residue on p65 measured at 3 hours post treatment, suggesting that it may be transcriptionally active (see discussion).
Contrary to previously published data, a subset of these molecules show strong interaction with the Z domain of SuRe®.
Such observations are however contrary to previously reported indications that lower-GIS are the predominant GIS during running [14].
Finally, we find that contrary to previously reported findings, versatility is lower in Eukaryotes.
The unexpected lower bioavailability of iron from the powdered supplement is contrary to previously published reports.
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