While the expression of different S100 members is commonly up-regulated in malignant tumors, distinct and in part contradictory expression profiles were observed in many cancers and may be attributable to cancer subtype, disease stage, cellular distribution, or issues associated with S100 protein and/or mRNA detection.
From our original expression analysis, we discovered that one GST gene (LOC_Os10g38470) matched two probe sets in the Affymetrix rice GeneChip and the two probe sets revealed contradictory expression profiles.
In poor prognosis (includes decreased overall survival, disease free survival, or response to therapy) AML, our comparison showed increased expression of several HOX/TALE genes, specifically HOXA4, HOXA10, HOXB5 and PBX1, while showing decreased expression of MEIS1 and contradictory expression directions of HOXB2 and PBX3.
The meta-analytical framework supported the identification of genes with consistent overall expression patterns and eliminated genes that exhibited contradictory expression patterns across studies.
Consequently, the contradictory expression of the liver iron homeostasis transcripts may be due to the red blood cells entering the liver.
They evidenced either contradictory expression ratios or missing spots [ 39, 40] but also a vast majority of expression patterns which differed only in the magnitude of the differential expression [ 41].
However, one of the genes, OsPP9, which was found to be down-regulated in microarray data, showed a contradictory expression pattern and was up-regulated in real time expression analysis.
Identification of modules showing contradictory expression under different conditions (e.g. upregulated in one dataset and downregulated in another) also suggests points of cross-talk within the regulatory network.
When I asked someone who has known the principals at Facebook for years about how Apple and Facebook view each other, he e-mailed me back a litany of somewhat contradictory emotions, using expressions like "mutual respect," "cold and distrustful," "not friends" and wanting to "find a way to work together".
To reconcile these contradictory observations, the expression of green fluorescent protein (GFP) from T7 constructs was evaluated in tobacco protoplasts.
