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While the expression of different S100 members is commonly up-regulated in malignant tumors, distinct and in part contradictory expression profiles were observed in many cancers and may be attributable to cancer subtype, disease stage, cellular distribution, or issues associated with S100 protein and/or mRNA detection.
From our original expression analysis, we discovered that one GST gene (LOC_Os10g38470) matched two probe sets in the Affymetrix rice GeneChip and the two probe sets revealed contradictory expression profiles.
In poor prognosis (includes decreased overall survival, disease free survival, or response to therapy) AML, our comparison showed increased expression of several HOX/TALE genes, specifically HOXA4, HOXA10, HOXB5 and PBX1, while showing decreased expression of MEIS1 and contradictory expression directions of HOXB2 and PBX3.
Consequently, the contradictory expression of the liver iron homeostasis transcripts may be due to the red blood cells entering the liver.
Identification of modules showing contradictory expression under different conditions (e.g. upregulated in one dataset and downregulated in another) also suggests points of cross-talk within the regulatory network.
The meta-analytical framework supported the identification of genes with consistent overall expression patterns and eliminated genes that exhibited contradictory expression patterns across studies.
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Taiji and wuji are opposed, apparently contradictory, expressions.
To reconcile these contradictory observations, the expression of green fluorescent protein (GFP) from T7 constructs was evaluated in tobacco protoplasts.
However, the physiological significance of this is yet unknown, and seems somewhat contradictory since basal expression of LH is decreased in autumn.
However, there is no conclusive explanation for the contradictory observation that expression of Nr5a2 is up-, buthatat of Cyp11a1 is down-regulated in FL1, in spite of the fact that Nr5a2 is a positive regulator of steroidogenic genes.
Epithelial growth factor receptor is a well-known target for anti-cancer therapies but the literature concerning the degree and frequency of EGFR overexpression in colorectal cancer is contradictory, with reported expression varying from 33%to97%7% of cases (Koretz et al, 1990; Lee et al, 2002; Spano et al, 2005; Bhargava et al, 2006).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com