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These results indicate that the in vivo reconstituted FIX after liver gene therapy depletes FIX-specific BMEM, leading to progressive contraction of the pool of PCs secreting high-affinity inhibitory anti-FIX IgG.
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In other words, a contraction of the potassium pool is per se sufficient to explain the occurrence of hyponatremia, in agreement with Edelman's equation.
After an immune response, homeostasis depends on the efficient contraction of the expanded T effector pool.
The effect of a reduction in naïve T cells in the peripheral pool is the contraction of the T cell repertoire leading to poor T cell responses to new antigens (see review by Nikolich-Zugich [ 8]).
Adequate levels of reduced sulfur compounds, such as Cys and GSH, would repress gene expression through a negative feedback loop preventing excessive sulfate uptake and reduction; vice versa a contraction of GSH pools would de-repress gene transcription allowing sulfate to enter the pathway.
Neal climbed out of the pool.
She climbs out of the pool.
Lance Armstrong is pulling out of the pool.
Get out of the pool.
Find the length of the pool.
Get on the edge of the pool.
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