The authors there gave an example of a function which is contraction in the category of cone metric spaces but not contraction if considered over metric spaces and hence, by proving a fixed point theorem in cone metric spaces, ensured that this map must have a unique fixed point.
They also gave an example of a function which is a contraction in the category of cone metric but not contraction if considered over metric spaces and hence by proving fixed point theorem in cone metric spaces ensured that this map must have a unique fixed point.
Lipid (fatty acid degradation), energy (oxidative phosphorylation), carbohydrate metabolism (pyruvate metabolism, glycolysis/gluconeogenesis) and circulatory system (cardiac muscle contraction) were most prominent categories in functional contrasts displayed for the heart in Fig. 7.
A diagnosis system permitted us to discriminate between these different categories of contractions.
In addition, we found also over represented the functional categories of muscle contraction and development linked to muscle wasting state, and of insulin signalling pathway that have been extensively associated to muscle hypertrophy and atrophy.
Enriched biological processes were mainly related to Ca2+ signaling or homeostasis, muscle contraction and cytoskeleton, including all the categories indicated above plus specific categories such as "calcium-mediated signaling", "calcium ion homeostasis" and "actin cytoskeleton reorganization".
We found three additional hybrid blp bacteriocin genes, resulting from the contraction of blpM + blpN in Categories 21 and 30, and blpQ + blpM in Category 26.
Remarkably, the third transcription pattern of the trajectory 1-5-7-8-11, that identifies the most contributing transcripts in the switch from point 8 to point 11, reveals contraction of the immune response category and NFκB network as compared to the point 6 of the trajectory 156 (see Additional file 1 Table S12 and S16).
The general contraction of the signaling pathway category, as identified by the major transcription pattern, that includes reduction in the one of the NFκB regulators - MAPK pathway, may explain a drop of the NFκB network activity after p53 inactivation at point 11.
The vascular smooth muscle contraction pathway (circulatory System sub- category) and gap junction pathway (cell communication sub-category) were consistently down-regulated in the 100 vs. 80 days and 110 vs. 80 days comparisons, and then up-regulated in the 110 vs. 100 days comparison.
