Thus, the Y27632-induced bending and altered dynamics of filopodia are probably due to alterations in organization of the core actin bundle of each filopodium and to the expected alteration in cell-body contractility caused by reductions in contractile stress fibers.
Cardiac tissues could be cultured for over three weeks without declines in contractile stress.
Only the 9 kPa microtissues exhibit organized sarcomeric structure and significantly increased contractile stress.
Cells cultured in osteogenic medium had greater expression of smooth muscle markers and correspondingly increased contractile stress responses.
Moreover, the patterned hiPSC-CMs within the constructs exhibit significantly greater levels of contractile stress, beat frequency, and contraction-relaxation rates, suggesting their improved maturation.
In analogy to the actomyosin-based force production mechanism in striated muscle, it was originally proposed that contractile stress in the actomyosin ring is generated via a sliding filament mechanism within an organized sarcomere-like array.
We propose that contractile stress transmitted from the apoptotic cell through E-cadherin adhesions elicits a mechanosensitive response in neighbor cells that is necessary for the morphogenetic event of apoptotic extrusion to occur.
Progenitor-derived myocardium had significantly less contractile stress and slower longitudinal conduction velocity than neonate-derived myocardium, indicating that the developmental state of the cardiomyocytes affects the electromechanical function of the resultant engineered tissue.
In this case, the generated contractile stress ∑ remains constant.
Inhibition of the contractile stress leads to dissolution of cytoskeleton and disappearance of FAs [13].
Figure 6B indicates a plot of the calculated peak contractile stress vs. film thickness.
