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In addition to highlighting cell-type differences in baseline contractility, these results demonstrate that both cell stiffness and de-adhesion reflect the contractile state of the cell.
It was seen that the diseased contractile state increased anterior leaflet strain compared to the healthy contractile state.
The benefits of drugs designed to influence the myocardial contractile state (positive inotropes) have not been fully evaluated.
The release of endothelial nitric oxide in the uterine vascular beds depends on the basal contractile state of the vasculature.
Activated PKG-1α performs important roles both in blood vessel vasodilation and in maintaining the smooth muscle cell in a differentiated contractile state.
Syndecan-1 knockout vascular smooth muscle cells also had elevated levels of Rho-associated protein kinase-1 (Rock1), leading to increased cell stiffness and an enhanced contractile state in the cells.
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A canonical model of muscle α-tropomyosin (Tpm1.1), based on molecular-mechanics and electron microscopy of different contractile states, shows that the two-stranded coiled-coiled is pre-bent to present a specific molecular-face to the F-actin filament.
Experimental studies under differing heart rates and contractile states, in both normal and diseased hearts, have shown that the elastance function can be reduced to a universal non-dimensional curve (Suga and Sagawa 1974).
In the final analysis of genes that were more active in control compared to IPF myofibroblasts in the non-contractile state, we found a striking enrichment of genes involved in cell cycle regulation (Table S8).
The analysis indicates that there is a large set of genes that are regulated at the translational level whose differential expression cannot be appreciated at the transcriptional level (see both the q-value analysis and the fold-change analysis in Figure 3) in both the contractile and the non-contractile state.
Pooling of blood and vasodilation in notch3 mutants are consistent with a role for notch3 in promoting the mature, contractile VSMC state to regulate vascular tone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com