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Cells supplemented with isoprenaline exhibited increased contractile frequency and acceleration.
A tendency toward return of SO basal pressure and contractile frequency to baseline was also observed.
We hypothesised that extracellular ATP was involved in the control of myometrial contractile frequency and/or force.
Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency.
Inhibition by L-Mee increases contractile frequency in non-laboring tissues consistent with removal of a relaxation influence on the muscle.
The stretch-activated channel toxin (GsM Tx-4) and the TREK-1 more selective channel inhibitors methionine ethyl ester and fluphenazine altered myometrial tension and contractile frequency consistent with the activity of TREK-1 currents in pregnancy myometrium.
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Moreover, the patterned hiPSC-CMs within the constructs exhibit significantly greater levels of contractile stress, beat frequency, and contraction-relaxation rates, suggesting their improved maturation.
Under these conditions, we observed a decrease in the contractile force following high frequency stimulation, while the low frequency component is not significantly altered (Fig. 2A).
Thus, the frequency of contractile waves of ICG-laden lymph propelled along the lymphatic vessels was measured by assessing the number of fluorescent pulses or "packets" arriving at a ROI.
Our studies indicate that in young skeletal muscle, SOCE contributes to maintenance of contractile force under high frequency stimulation, where Ca2+ requirements may exceed the capacity of the intracellular store to provide for sustained and repetitive contractions, almost as if there is a fatigue component to the SOCE regulation of contractile force.
As with chelation of [Ca2+]o by EGTA we found that Ni2+ has more pronounced effects on the contractile force developed during high frequency stimulation than during low frequency stimulation, further suggesting that under conditions of high Ca2+ demand, [Ca2+]o exerts a more significant role in skeletal muscle contractility.
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