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The LGI of a vertex corresponds to the ratio of the surface area of the folded pial contour ("buried" surface) to the outer contour of the cortex ("visible" surface) included within spherical regions of interest (25 mm radius).
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The contours of the cortex, or hippocampus areas, of both contralateral and ipsilateral were traced as virtual overlay on the steamed images.
The contour of the segmented cerebral cortex was used to define the VOI of the reference region.
The Neurolucida plots containing partial section contours of the insular opercular cortex and architectonic borders identified in Nissl, PV, SMI-32, AChE, and myelin series were exported as vector data to Adobe Illustrator.
For the right and left striatum and left and right occipital cortex, a template with irregular ROIs, according to the contour of the striatum and occipital cortex, was positioned on four consecutive axial slices with highest striatal activity.
Cortical thickness is often not measurable at the 4% level of the distal tibia/radius, as cortical thinning leads to inconsistencies in the cortical shell contour, although the cortex was clearly visible on visual inspection of HBM pQCT images.
Distal femora are enlarged, and periostitis is visible as a wavy contour (arrows) of the outer cortex.
Standard templates (according to the contour of the caudate nucleus, putamen and occipital cortex) with fixed ROIs were manually positioned, without changing size and shape, on the five consecutive axial slices with the highest striatal activity to calculated the mean striatal and mean occipital binding by averaging right and left ROIs.
For trabecular analysis, 200 slices of the femur above the patella were traced and contoured inside the cortex.
The size of the cortex is (4times2pi).
Two ROI were contoured, one including the cortex (Cortical ROI) and the other including most of the brain (Brain ROI).
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