Highly qualified demographers, epidemiologists, sociologists, clinicians and economists enable a continuum of research and a multi-faceted examination of health problems and provide an ideal environment for training of research professionals.
Across the continuum of research we suggest three strategies to minimise the impact of authorisation bias at the inception, reporting, and interpretation of research.
Across that continuum, different research strategies have various strengths.
As Shire's career path illustrates, regulatory science includes a broad range of responsibilities and a firm understanding of both the drug-development process and the continuum of research and regulations along that process.
However, identifying the core tenets that support all pharmaceutical services along the continuum from research to public health and allow for a grounded foundation and framework with flexibility for adaptation (based on local needs) is a key principle.
Our novel approach to therapy design for paediatric CP addresses 'the gaps in the continuum of translational research and the WHO-ICF framework' in order to 'increase the clinical and societal relevance of rehabilitation research throughout the NIH and is thus consistent with recommendations by the Blue Ribbon Panel on Rehabilitation Research' (NIH, June 2012).
Integrating these skills along the continuum from laboratory research to the practice of medicine is a constant challenge for trainees; they seek to allocate their time and talents to maximize their contribution to medical science.
Health improvements seen both for individuals and populations are fully dependent upon the quality of validation of new scientific discoveries within the CTM research continuum and strong evidence of benefits and risks associated with therapeutic interventions.
The identification of rapamycin from Streptomyces hygroscopicus as an antifungal agent, through being an immune inhibitor to being an effective anticancer drug, demonstrates a research continuum driven by clinical observations that were critical in the elucidation of the mTOR pathway.
This chapter reviews several notable clinical trial designs, emphasizing the importance of matching the specific design selected to both the purpose of the trial and where the specific question being addressed sits on the spectrum of the research continuum.
