While Tregs are easily defined in mice by concurrent expression of FOXP3 and high levels of CD25, in humans CD25 cannot be clearly delineated into low and hi expressing subsets due to a continuum of expression.
For us street art is a conversation, a continuum of expression, and Swoon is always a part of it.
CD25 expression in humans appears as a continuum of expression rather than a discrete positive and negative population, therefore to ensure reproducible gating, CD25 was gated by selecting the total CD3+ population and plotting CD25 against CD4.
The data suggest that many miRNAs may lack complete tissue specificity, instead show a continuum of expression variability in different tissues/cells and physiological/pathological states.
A continuum of expression from the Xi, from zero to a maximum of approximately 70% of the level seen from the Xa was observed in humans [ 23], and similarly in Table 1, expression levels varied from the Xi in mice.
In some instances, the social strategies adopted by a microbe may be characterized by a continuum of expression levels of the cooperative genes as a function of the actions of other cells in the population.
In addition to observing a continuum of expression from the Xi, examination of allelic imbalance of histone modifications demonstrated a gradation of histone modifications on genes subject to or escaping from XCI [ 23].
Their findings support our study, since there was down-regulation of miR-34c expression in their COPD patients, compared to controls, and also down-regulation in our moderate emphysema patients, compared to mild emphysema, indicating a similar continuum of expression with increasing disease severity.
There is a continuum of expression of cardiac structural and functional alterations that occurs with age in healthy humans, and these age-associated cardiac changes seem to have relevance to the steep increases in left ventricular hypertrophy (LVH), chronic heart failure, and atrial fibrillation (AF) that are seen with increasing age [ 30].
As Sylvia Maracle observes, work is being done to help Indigenous men become reoriented, to unlearn the harmful behaviours some of which, she believes, stem from Indigenous people adopting "limited notion of gender, instead of a continuum of gender expression".
