Sentence examples for continuum of differentiation from inspiring English sources

Our 3-D co-culture system sustains the ECMs in vitro continuum of differentiation process and simultaneously induces the maturation and differentiation of BMSCs into cardiomyocyte-like cells.

PAX3 expression seems to correlate with undifferentiated (co-expressing HES1 and MITF) and differentiating (co-expressing MLANA and MITF) cells, whereas it might be diminished in terminally differentiated cells (PAX3-negative but MLANA or MITF-positive) that are further along the continuum of differentiation.

Comparison of Δ between transitional zones was performed by dividing the estimated FPKM for a given (X) in the region ahead in the continuum of differentiation (lens cell differentiation proceeds stepwise EC to EQ, EQ to FP, and FP to FC) of the estimated FPKM for the given (X) from the region before in the continuum of differentiation.

These subpopulations have not been fully characterised but may reflect the continuum of differentiation from quiescent fibroblast (vimentin-positive, α-SMA negative, desmin negative) to myofibroblast (α-SMA positive, vimentin and/or desmin positive).

We also observed that the proportion of cells with C19MC amplification and/or LIN28 expression varied across tumor samples that share group 1 CNS-PNETs molecular signatures, thus indicating that histopathologic analyses may be confounded by intra-tumoral heterogeneity which may reflect a varying, continuum of differentiation in the tumors.

Instead, recently diverged taxa might express continuous variation at the population level, whereas segments of older taxa might have already 'decayed' into a ring of closely related species (see [ 16]), thus making it unlikely that researchers would detect a near continuum of differentiation.

The chondrocyte column in the growth plate represents a continuum of cellular differentiation from proliferative cells proximal to the hypertrophic cells distally (Fig. 1D,E) (Farnum et al., 1990).

Significant data support the notion that the distinction between luminal A and B tumors may be more of a continuum of proliferation, differentiation, and accompanying HER2 expression, leading to difficulty in clinical cutoffs and decision-making.

Similarly, CNT and RNT cells appear in a continuum of neural differentiation and there is no overall change in transcriptome size from the CNT to the RNT (Table 1).

Taken together, our data shed new light on NK cell physiology and suggest a continuum of NK cell differentiation.

Differentiation-state analysis of embryonic chicken lenses was performed after microdissection of 100 E13 chicken lenses into four distinct regions that represent a continuum of lens cell differentiation states: lens central epithelium (EC), equatorial epithelium (EQ), cortical fibers (FP), and central fibers (FC) as described previously (Walker and Menko 1999).