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The ET receptor gene EIN4 that acts upstream of constitutive triple response 1 (CTR1) was continuously upregulated.
These included continuously upregulated BCL2A1 (anti-apoptotic), early upregulated MCL1 (myeloid cell leukemia sequence 1) (anti-apoptotic), BMF (BCL2 modifying factor) (pro-apoptotic) and PMAIP1 (pro-apoptotic), late (48 hours) downregulated BCL2 and dynamically (up-down-up) regulated BBC3 (pro-apoptotic).
In kidney cortex, ten genes were significantly regulated at all exposures, including two probe variants for the Per1 gene (Figure 3A), all of which were continuously upregulated.
It was observed to be continuously upregulated in the acute phase of BM [2].
CFLAR (CASP8 and FADD-like apoptosis regulator) was significantly and continuously upregulated.
As downstream target of ATF4, we examined GADD34, and this was continuously upregulated over time.
Similar(36)
In contrast to the small discrete perturbation in LSA, we perturbed E3 by continuously varying βTE3 or KTE3 such that E3 was upregulated initially and downregulated subsequently, and measured the steady-state levels of the system components.
Another gene cluster, comprising the stress response genes, was continuously induced by 1 μM RITA, but only transiently upregulated by Nut and 0.1 μM RITA (cluster 0004 in Figure 1a).
In the later-response type, the Hsf gene expression levels were not instantly upregulated or inhibited after heat shock, but slowly and continuously increased during plant recovery from cell damage.
However, when Stat3 is highly and sustainably activated by GCSF in B6-S3Y118F mESCs, the expression of Tfap2c can be continuously induced and consequently upregulates Cdx2 expression.
Since VEGFR1 expression was upregulated within minutes of exposure to VEGF, we hypothesized that VEGFR1 was continuously being degraded by the ubiquitin-proteasome system to maintain its homeostatic levels.
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