Such temporal and geographical dimensions continuously reshape the antigenicity of physical entities (molecules, cells, bacteria, viruses), create new targets of oral tolerance or rejection, and challenge the status of unexpected self epitopes produced by proteasome splicing (ibid).
In tropical forests, natural disturbances caused by the death of one or more trees are the dominant forms of forest regeneration as the creation of canopy openings continuously reshapes forest structure (Goulamoussène et al. 2017).
Behind these events lay processes of change that continuously reshape risk to sustainable development, adding not only to the complexity of the world but also to its dynamic character.
In 1958, Daniel Koshland suggested a modification to the lock and key model: since enzymes are rather flexible structures, the active site is continuously reshaped by interactions with the substrate as the substrate interacts with the enzyme.
In particular, climate-driven range fluctuations during the Pleistocene have continuously reshaped genetic structure within species.
In dividing cells, for example, the microtubule cytoskeleton is continuously reshaped, changing dramatically from interphase to mitosis.
The tumor metabolic microenvironment, which is continuously reshaped during tumor progression can influence adaptive cellular behaviors including dormancy, invasion, and metastasis as well as therapy resistance.
The Romanian people derive much of their ethnic and cultural character from Roman influence, but this ancient identity has been reshaped continuously by Romania's position astride major continental migration routes.
It is continuously reworked and reshaped and reformed by time, place, and people.
