Combined, the findings suggest that ara-C neurotoxicity in DRG neurons originates in mitochondria and that continuous mtDNA synthesis and reliance on oxidative phosphorylation for energy needs sensitize the highly metabolic neurons to injury by mtDNA synthesis terminating cancer drugs.
How will you win (e.g., driving disciplined management, continuous process improvement, building reliance and best business practices)?
For Jenkin, Darwin's reliance on continuous additive deviation was presumed undermined by this argument, and only more dramatic and discontinuous change something Darwin explicitly rejected could account for the origin of new species.
This study has several strengths such as the large sample size and the reliance on continuous data for MetS traits, as well as the use of statistical methods such as GEE which allowed us to tackle the dependence among family members.
In contrast, our reliance on a continuous rating scale in the current study necessitated estimation of the effects of non-affective cues across a broad range of affect, even though sensitivity to some affective cues appeared in prior work to be unrelated to values of non-affective cues.
Despite government's and donors' continuous efforts to promote Integrated Pest Management (IPM) [ 8] reliance on chemical pesticides has been growing in Nepal.
In the context of the current continuous-rating paradigm, these robust findings suggest that reliance on affect might be potentiated by provocative clothing style, attractiveness, and sexually relevant contexts.
With continuous privatization of the waterfront coast for luxury developments and reliance on foreign investment, Aqaba is at risk to develop into an unsustainable model of growth.
Unlike the majority of woodland montane fauna whose continuous habitat allows for cross-valley dispersal among mountain ranges, pikas reliance on high-elevation talus habitat precludes their ability for dispersal to cooler latitudes [ 9].
The policies underlying the exclusionary rule do not require retroactive application of Almeida-Sanchez where, as here, the agents were acting in reliance upon a federal statute supported by longstanding administrative regulations and continuous judicial approval.
