These results may be partially explained by the bedside follow-up and continuous attention to the rationale for SGC by the project-nurses.
The optimal duration of treatment with an agent such as bevacizumab was unclear, but preclinical studies had demonstrated VEGF maintained tumor vessel morphology, providing a rationale for continuous anti-VEGF therapy.
'Practice' is key here, as it captures how the potential reversibility of epigenetic marks grounds the rationale for continuous intervention and/or maintenance that may safeguard their plastic and hence vulnerable states.
There is increasing evidence of the central role of the VEGF/VEGFR pathway in the development of a/mRCC and good rationale for continuous inhibition of this pathway due to the frequent mutation of the VHL tumour suppressor gene in RCC (also seen in sporadic forms of the disease).
Regarding the rationale for continuation of trastuzumab monotherapy, the ToGA (as shown in Fig. 3) and HERA trials demonstrated that continuous treatment with a single agent was capable of inhibiting HER2-positive tumor growth.
The rationale for creating a continuous metabolic syndrome score stems mainly from the fact that there is no clear definition of the metabolic syndrome in children or adolescence and the prevalence rate is relatively low.
The results indicate the advantage of continuous administration of angiogenic inhibitors and provide rationale for using such delivery methods for cancer treatment.
The rationale for the inclusion of continuous noradrenaline infusion in the therapeutic regimen was (i) to closely mimic the patients' conditions on ICUs and (ii) to avoid hypotension-induced coronary hypoperfusion with subsequent cardiac depression due to ischemia.
In this way, the drug centred model provides a rationale for periodic rather than continuous drug use, to cope with exacerbations of symptoms or to palliate stressful environmental events and avoid the harm associated with long term use.
This strengthens the rationale for the use of infusional or continuous oral treatment schedules in NET therapy.
This highlights the continuous interest in laboratory screening of medicinal plants, not only to determine the scientific rationale for their usage, but also to discover new active principles.
