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A systematic framework is proposed for the design of continuous pharmaceutical manufacturing processes.
In this book chapter, the model-based design of control system for continuous pharmaceutical tablet manufacturing process has been described.
The continuous pharmaceutical manufacture (CPM) plant and control architecture developed earlier is currently being widely implemented in industries [1,2].
Furthermore, a simplified version of the synthesized control structure was applied experimentally to an end-to-end continuous pharmaceutical pilot plant.
The process model is an important "virtual experimentation tool" that can be effectively used to design and evaluate a control system for continuous pharmaceutical manufacturing.
The control system has been designed for three continuous pharmaceutical manufacturing routes, namely, via direct compaction, via roller compaction, and via wet granulation.
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A novel design of pilot-scale continuous flow pharmaceutical fixed-bed catalytic reactor has been developed.
This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective.
In conclusion, the developed structured compact reactor was demonstrated as a promising alternative to replace conventional batch reactors and establish continuous synthesis of pharmaceutical intermediates and specialty chemicals.
On the basis of the quality by design approach, aggregation of knowledge in process chemistry and manufacturing operations is essential for the continuous development of pharmaceutical products and processes.
PAT is critical to pharmaceutical continuous processing.
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